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   synthesis and cyclization of β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity  
   
نویسنده shehab wesam s. ,el-bassyouni gehan t.
منبع journal of the iranian chemical society - 2018 - دوره : 15 - شماره : 7 - صفحه:1639 -1645
چکیده    Synthesis of biologically active new indole and pyrazole derivatives has earned a substantial position in the pharmaceutical industry. the study aims to synthesize and cyclize β-keto-enol derivatives tethered indole and pyrazole as potential antimicrobial and anticancer activity. novel derivatives of enolic keto ester 1 have been obtained through claisen condensation of 3-acetylindole with diethyl oxalate under basic conditions. spectral data of newly produced compounds were characterized using fourier transform infrared, hydrogen nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and elemental analysis. few compounds were assessed for their antimicrobial activity, contrary to gram-positive bacterial strains, gram-negative bacterial strain, and antifungal activity that have been approved against candida albicans. however, compound 2 showed an excellent antimicrobial activity. in vitro antitumor action of few prepared compounds in contradiction to human breast carcinoma cell line, colon cell line, and normal retina cell line was evaluated.
کلیدواژه antimicrobial ,anticancer ,cyclization ,derivatives ,pyrazole
آدرس zagazig university, faculty of science, chemistry department, egypt, national research centre (nrc), ceramics and building materials department, egypt
 
     
   
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