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   one-pot synthesis, spectroscopic characterization and dft study of novel 8-azacoumarin derivatives as eco-friendly insecticidal agents  
   
نویسنده rizk sameh a. ,elsayed galal a. ,el-hashash maher a.
منبع journal of the iranian chemical society - 2018 - دوره : 15 - شماره : 9 - صفحه:2093 -2105
چکیده    A series of sixteen 8-azacoumarin derivatives bearing aryl moieties at c-5 and c-7 was designed and synthesized by a concise and facile procedure utilizing grinding and ultrasound approaches. the efficient multi-component protocols proceeded smoothly and in the absence of solvent to furnish the target products in moderate to good yields. all the synthesized molecules were characterized via 1hnmr, 13cnmr, ir, mass spectra, and elemental analyses. the density functional theory (dft) was then used to discover the structural and electronic characteristics of such compounds. finally, an insecticidal study against plutella xylostella and helicoverpa armigera on the synthesized compounds is reported. the bioassay results indicated that some of the tested compounds showed potency ranging from good to moderate. in particular, analogs 6i and 6l, among the tested compounds, showed even more potency than commercial chlorpyrifos. on the other hand, the rest of the tested compounds showed moderate to weak activities.
کلیدواژه azacoumarin ,chalcones ,ultrasonic irradiation ,grindstone ,dft ,insecticidal activity
آدرس ain shams university, faculty of science, department of chemistry, egypt, ain shams university, faculty of science, department of chemistry, egypt, ain shams university, faculty of science, department of chemistry, egypt
 
     
   
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