synthesis, characterization, and antimicrobial studies of some palladium complexes with an octamethyl tetraazacyclotetradecadiene ligand and isomers of its reduced form

Biologically important tetraaza-macrocyclic ligand 3,10-c-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene dihydroperchlorate, me8[14]diene·2hclo4 (l1·2hclo4) was synthesized by the condensation of 1,2-diaminopropane with acetone in presence of quantitative amount of hclo4 and three isomeric ligands designated as la, lb and lc were separated by the reduction of l1·2hclo4 with nabh4 and fractional crystallization from xylene. the nitrato, nitro, bromido, and iodido complexes of palladium with diene ligand l1 were prepared by the interaction of l1·2hclo4 with k2[pd(no3)4], k2[pd(no2)4], k2[pdbr4], and k2[pdi4] (prepared by the reactions with pdcl2 with kno3, kno2, kbr, and ki, respectively), respectively. the bromide and iodido complexes of la were prepared by the axial substitution reactions with [pdlacl2]cl2. by contrast, similar complexes of other isomeric ligands lb and lc were prepared by axial addition reactions of [pdlʹ][pdcl4] (l′ = lb or lc) with kbr and ki, respectively. the complexes were characterized on the basis of elemental analysis: ir, 1h-nmr, uv–vis spectroscopic analysis, and magnetic and molar conductivity data. the antifungal and antibacterial activities of these compounds have been studied against some phyto-pathogenic fungi and bacteria.