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   pivaloyl chloride as a new derivatization agent for parabens and its application in simultaneous derivatization and air-assisted liquid–liquid microextraction of the analytes in hygiene and personal care products  
   
نویسنده farajzadeh mir ali ,aghdam mehri bakhshizadeh ,mogaddam mohammad reza afshar ,nabil ali akbar alizadeh
منبع journal of the iranian chemical society - 2019 - دوره : 16 - شماره : 10 - صفحه:2187 -2196
چکیده    An air-assisted liquid–liquid microextraction method using of an extraction solvent (less dense than water) has been proposed for simultaneous derivatization and extraction of some p-hydroxybenzoic acid esters (parabens) in different samples before their determination with gas chromatography-flame ionization detection. the analytes are derivatized by a fast reaction occurring between parabens and pivaloyl chloride (as a derivatization agent) and extracted into toluene (as an extraction solvent) under mild conditions in a test tube. after performing the microextraction procedure, a home-made device (an inverse funnel having a capillary tube) is placed into the tube. a thin film of the extractant accumulated on the surface of the aqueous phase is transferred into the capillary part of the device. a fraction of the organic phase is removed by a microsyringe and injected into the separation system for analysis. under optimum conditions, detection and quantification limits were between 0.60 and 1.0; and 1.7 and 3.1 ng ml−1 in solution; and 6.0 × 10−6 and 1.0 × 10−5; and 1.7 × 10−5 and 3.1 × 10−5 g kg−1 in solid, respectively. the enhancement and enrichment factors were obtained in the ranges of 492–650 and 380–410, respectively. relative standard deviations were less than 6% (n = 6) for intra- and less than 9% (n = 4) for inter-day precisions calculated at a concentration of 50 ng ml−1 of each analyte. the calibration graphs were linear with coefficients of determination ≥ 0.994. finally, the selected parabens were successfully analyzed in various hygiene and personal care products by the proposed method.
کلیدواژه gas chromatography ,hygiene ,parabens ,derivatization ,air-assisted liquid–liquid microextraction
آدرس university of tabriz, faculty of chemistry, department of analytical chemistry, iran. near east university, engineering faculty, turkey, university of tabriz, faculty of chemistry, department of analytical chemistry, iran, tabriz university of medical science, food and drug safety research center, iran, tabriz university of medical sciences, pharmaceutical analysis research center, iran
 
     
   
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