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green approach to synthesis of new series of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives
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نویسنده
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morshedi abdollah ,shaterian hamid reza
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منبع
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journal of the iranian chemical society - 2019 - دوره : 16 - شماره : 3 - صفحه:493 -500
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چکیده
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One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and 6-aminouracil for preparation of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been reported. the method involves domino knoevenagel condensation/michael addition, and cyclization cascade. the reaction was performed in glycerol which is commercially available, inexpensive and non-toxic compound. high purity of the products, very high yields and wide scope of substrates are advantages of this protocol.
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کلیدواژه
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8a-dihydropyrido[2 ,3-d]pyrimidine ,(phenylsulfonyl)acetonitrile ,glycerol ,green chemistry ,multi-component reactions
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آدرس
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university of sistan and baluchestan, faculty of sciences, department of chemistry, iran, university of sistan and baluchestan, faculty of sciences, department of chemistry, iran
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Authors
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