γ-aminobutyric acid hydrochloride supported on superparamagnetic γ-fe2o3@sio2 as a novel heterogeneous nanocatalyst for the synthesis of 2-amino-5-alkylidene-thiazol-4-one derivatives

Γ-aminobutyric acid hydrochloride immobilized on superparamagnetic γ-fe2o3@sio2 nanoparticles as a novel heterogeneous nanocatalyst was prepared for the first times. it was characterized by several techniques such as xrd, ft-ir, vsm, fe-sem, eds, and tga analysis. the heterogeneous nanocatalyst was used for a convenient, mild, and one-pot efficient three-component preparation of 2-amino-5-alkylidene-thiazol-4-one derivatives under green conditions at room temperature. the main advantage of the method is easily recovery of the stable nanocatalyst by an external magnet from the reaction mixture.