a water stable metal–organic framework with 1d nanotube pores for 5-fluorouracil delivery and anti-brain tumor activity

The employment of porous carriers for anticancer drug delivery has gained much attention in recent years for their excellent drug-loading capacity and controlled release performance. in this work, by utilizing a rigid organic aromatic carboxylic acid ligand, a new zn(ii)–organic framework {[zn2(bptc)(h2o)]·(dmac)3(h2o)4}n (1, dmac is in short of n,n-dimethylacetamide, h4bptc is in short of biphenyl-3,3′,5,5′-tetracarboxylic acid ligand), with considerable water stability has been prepared using the solvothermal technology. the structural analysis result reveals that complex 1 is constructed from fourfold helical metal chains whose net could be simplified into a (6,8)-connected topology. moreover, complex 1 shows 1d nanotube channels with a window size of 10.7 × 10.7 å2 along the [001] direction and reveals a large accessible voids of 51.7%. the desolvated 1 (1a) was used to study the loading and releasing of the 5-fluorouracil (5-fu), which reveals that 1a could uptake around 51.2 wt% of 5-fu and nearly 85.6% of the absorbed 5-fu could be released in pbs (7.4 for the ph value) in 100 h at 37 °c. in connection to these, in vitro cytotoxicity of compound 1 together with the anticancer performance of 5-fu-loaded 1a was evaluated against human oral epidermal cells and human brain tumor cells sf17 via mtt assays.