convenient synthesis of spirooxindoles using sno2 nanoparticles as effective reusable catalyst at room temperature and study of their in vitro antimicrobial activity

New highly efficient method for safe, green and facile synthesis of spirooxindole derivatives have been presented. sno2 nanoparticles (sno2 nps) as effective catalyst were synthesized through chemical precipitation method and characterized in details using ftir, xrd, sem and eds methods. obtained nano tin oxide particles were used as heterogeneous catalyst for the one-pot synthesis of spirooxindoles at room temperature. high–excellent yields of products, short reaction times, room temperature conditions and reusability of catalyst are the main advantages of this method. evaluation of antimicrobial activity of some synthesized compounds were performed against eight bacteria. agar diffusion method was used for determining preliminary antibacterial activities and to assess the bacterio-static activity of compounds with inhibition zone, micro-well dilution assay method was used. obtained results showed that (5j) was active against all tested microorganisms and was the most effective compound.