metal-ion-directed synthesis of two nanostructured coordination polymers: topological diversity and growth inhibition of human glioma cells

By using a trigonal hetero-donor linker 4,4′-(4,4′-bipyridine-2,6-diyl) dibenzoic acid (h2l), two 3-periodic coordination polymers (cps), namely {[cu(l)(meoh)](meoh)2}n (1) and [sr(l)(etoh)2]n (2), with different interpenetrated motifs have been effectively produced under solvothermal surroundings. the x-ray single-crystal data solution and refinement results showed that cp 1 comprises of a fourfold interpenetrated srs2-type topological structure, and compound 2 comprises of a 3d twofold interpenetrated thsi2-type topological structure, which are controlled by their metal ions used. furthermore, the morphologies of the two cps could be reduced to nanometers via a green hand grinding technique. in connection to these, we studied the cytotoxic activity of the nanostructures 1 and 2 against two human glioma cells a172 and u251 via the mtt assay.