|
|
the organocatalytic highly enantioselective knoevenagel condensation: applications in the synthesis of various chiral amide derivatives
|
|
|
|
|
نویسنده
|
ashokkumar veeramanoharan ,siva ayyanar ,sankar balakrishnan
|
منبع
|
journal of the iranian chemical society - 2019 - دوره : 16 - شماره : 9 - صفحه:1939 -1955
|
چکیده
|
In this work, efficient organocatalysts were designed, synthesized and successfully applied to the knoevenagel condensation. in this reaction, different α-branched aldehydes were treated with various malonate compounds to give the desired products up to 97% yield and excellent e.r up to 99.68:0.32 under the mild reaction conditions. moreover, the knoevenagel product was converted into different chiral amide derivatives in higher enantioselectivity. we have designed and synthesized efficient chiral organocatalysts and successfully applied to the knoevenagel condensation reaction. in this reaction, the different α-branched aldehydes were treated with various malonate derivatives to give enantiomerically enriched knoevenagel products with higher chemical yield (up to 97%) and excellent e.r up to 99.68 0.32 via dynamic kinetic resolution. further the knoevenagel adduct was converted into enantiomerically enriched valuable γ-alkyl-substituted amides without loss in enantiomeric ratio.
|
کلیدواژه
|
organocatalysts ,enantioselectivity ,knoevenagel condensation ,dynamic kinetic resolution ,chiral amide
|
آدرس
|
madurai kamaraj university, school of chemistry, supramolecular and organometallic chemistry lab, india, madurai kamaraj university, school of chemistry, supramolecular and organometallic chemistry lab, india, madurai kamaraj university, school of chemistry, supramolecular and organometallic chemistry lab, india
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|