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Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: antibacterial activity
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نویسنده
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Atef M. Abdel Hamid ,W. Shehta
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منبع
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journal of the iranian chemical society - 2018 - دوره : 15 - شماره : 12 - صفحه:2771 -2779
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چکیده
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the starting material 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile 3 was reacted with various reagents resulting in the formation of a group of new pyrimidines and condensed pyrimidines including quinazoline 6 tetrazolopyrimidine 12, pyrazolopyrimidines 14, 18, and 19, triazolopyrimidine 16, and pyrimidopyridazine 20. the antibacterial activity was evaluated for a group of the synthesized compounds against examples of gram-positive and gram-negative bacteria.
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کلیدواژه
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Pyrazolopyrimidine ,Triazolopyrimidine ,Pyrimidopyridazine ,Cyclocondensation ,Antibacterial
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آدرس
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Zagazig University, Department of Chemistry, Egypt, Zagazig University, Department of Chemistry, Egypt
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Authors
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