a study of sonodynamic therapy of melanoma c540 cells in vitro by titania/gold nanoparticles

Background: sonodynamic therapy (sdt), a safe and non-invasive strategy in tumor therapy, is in development using novel sono-sensitizers, activated by low-intensity ultrasound radiation. sdt mainly progresses through reactive oxygen species (ros) generation followed by cell annihilation. objective: the current study aimed to investigate the effect of ultrasound therapy with titania/gold nanoparticles (nps) on melanoma cancer.material and methods: in this experimental study, titania/gold nps (tgnps) were synthesized, and their activity was investigated in sonodynamic therapy of a melanoma cancer cell line (c540). sdt was performed at 1.0 w cm^-2 and 1.0 mhz for one minute. results: the synthesized nps that comprised gold nps of <10 nm into titania nps of <20 nm showed great stability and cytocompatibility. while tgnps were biocompatible, a remarkable rate of cell ablation was observed upon ultrasound irradiation due to ros generation. conclusion: the sdt using tgnps can be introduced as an alternative and low-cost treatment method for melanoma malignancy.