magnetic targeting of magneto-plasmonic nanoparticles and their effects on temperature profile of nir laser irradiated to ct26 tumor in balb/c mice

Background: photothermal therapy (ptt) is a promising method in the field of cancer hyperthermia. in this method, interaction between laser light and photosensitizer material, such as plasmonic nanoparticles, leads into a localized heating. recent efforts in the area of ptt aim to exploit targeting strategies for preferential accumulation of plasmonic nanoparticles within the tumor. objective: to investigate the impact of magnetoplasmonic (au@fe2o3 ) nanoparticles on temperature profile of ct26 tumor, bearing mice were irradiated by nir laser.material and methods: in this in vivo study, au@fe2o3  nps were injected intraperitoneally to balb/c mice bearing ct26 colorectal tumor. immediately after injection, a magnet (magnetic field strength of 0.4 tesla) was placed on the tumor site for 6 hours in order to concentrate nanoparticles inside the tumor. in the next step, the tumors were exposed with nir laser source (808 nm; 2 w/cm2; 5 min). results: tumor temperature without magnetic targeting increased ~7 ± 0.9 °c after nir irradiation, whereas the tumors in magnetic targeted group experienced a temperature rise of ~12 ± 1.4 °c. conclusion: it is concluded that au@fe2o3 nanoparticle is a good candidate for therapeutic nanostructure in cancer photothermal therapy.