hesperidin modulates troponin-1 serum level and decrease heart tissue injury of irradiated rats

Background: the heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region. objective: this study aims to investigate the radio protective effects of hesperidin (hes) as a natural flavonoid after localized irradiation of the rat’s mediastinum region.material and methods: in this experimental study, we divided sixty male rats into 4 groups (n=15). first group: sham which received pbs; second group: hesperidin only (100 mg/kg/day orally) for one week; third group: radiation that received single dose of 20 gy gamma radiation using co-60 unit and the forth group: radiation+hes that underwent the same dose of radiation and received hes for 7 days prior irradiation. each group was divided in two branches. early sampling from subgroup one was done 46 hours after irradiation to determine troponin-1 level changes. rats of second subgroups were killed 56 days after irradiation for histopathological evidence. results: in radiation group, troponin-1 serum level had a significant increase in comparison with sham group (p< 0.05). histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. inflammation (p=0.008), pericardial effusion (p=0.001), and vascular plaque (p=0.001) had an increase in the irradiation group. oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (p< 0.016). conclusion: oral administration of hesperidine for seven days prior radiotherapy may decrease troponin1 and cardiac injury due to radiation.