extracting mutual interaction rules using fuzzy structured agent-based model of tumor-immune system interactions

Background: there are many studies to investigate the effects of each interacting component of tumorimmune system interactions. in all these studies, the distinct effect of each component was investigated. as the interaction of tumorimmune system has feedback and is complex, the alternation of each component may affect other components indirectly.objective: because of the complexities of tumorimmune system interactions, it is important to determine the mutual behavior of such components. we need a careful observation to extract these mutual interactions. achieving these observations using experiments is costly and timeconsuming.material and methods: in this experimental and based on mathematical modeling study, to achieve these observations, we presented a fuzzy structured agentbased model of tumorimmune system interactions. in this study, we consider the confronting of the effector cells of the adaptive immune system in the presence of the cytokines of interleukin2 (il2) and transforming growth factorbeta (tgfβ) as a fuzzy structured model. using the experimental data of murine models of b16f10 cell line of melanoma cancer cells, we optimized the parameters of the model. results: using the output of this model, we determined the rules which could occur. as we optimized the parameters of the model using escape state of the tumor and then the rules which we obtained, are the rules of tumor escape. conclusion: the results showed that using fuzzy structured agentbased model, we are able to show different output of the tumorimmune system interactions, which are caused by the stochastic behavior of each cell. but different output of the model just follow the predetermined behavior, and using this behavior, we can achieve the rules of interactions.