glucosamine conjugated gadolinium (iii) oxide nanoparticles as a novel targeted contrast agent for cancer diagnosis in mri

Background: glucose transporter (glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.objective: in this study, we evaluated a magnetic resonance (mr) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (gd2o3) coated polycyclodextrin (pcd) and modified with glucose (gd2o3@pcd-glu) for the targeting of overexpressed glucose receptors.material and methods: in this experimental study, 3t magnetic resonance imaging (mri) scanner was used to assess the specific interactions between glut1overexpressing tumor cells (mda-mb-231) and gd2o3@pcd-glu nps. furthermore, the capacity of transporting gd2o3@pcd-glu nps to tumor cells was evaluated. results: it was found that the acquired mri t1 signal intensity of mda-mb-231 cells that were treated with the gd2o3@pcd-glu nps increased significantly. based on the results obtained, gd2o3@pcd-glu nps can be applied in targeting glut1overexpressing tumor cells in vivo, as well as an mri-targeted tumor agent to enhance tumor diagnosis. conclusion: results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.