histopathologic evaluation of radio-protective effect of hesperidin on the liver of sprague dawely rats

Background: hesperidin is a bioflavonoid glycoside mainly found in citrus fruit and has been shown radio-protective potential in various measurement systems. objective: in this article aims to investigate the radio-protective effect of hesperidin on the liver of sprague dawely rats. material and methods: in this clinical study, 40 male rats were selected randomly and divided into 8 groups. group 1 did not receive radiation and hesperidin (sham control). group 2 received only 100 mg/kg body weight (b.w) of hesperidin for 7 consecutive days (hes group); group 3 exposed to dose of 2gy whole body gamma radiation (2gy group), and group 4 and 5 received 50 and 100 mg/kg b.w of hes for 7 consecutive days before 2 gy gamma radiation, respectively.group 6 exposed to dose of 8gy gamma radiation (8gy group); group 7 and 8 received 50 and 100 mg/kg b.w of hes for 7 days before 8gy gamma irradiation, respectively. histopathological evaluation was perfomred 24 hours after radiation. results: administration of hesperidin (50 mg/kg b.w, 7 days) before 2gy of gamma irradiation led to remove inflammatory mononuclear cells in the portal space. microscopic findings in the groups receiving two doses of hesperidin (50 and 100 mg/kg b.w, orally, 7 days), before 8gy of gamma radiation, were similar in a way that extreme dilation of central veins to be seen, however, there was no capillarization. conclusion: hes can be offered as a suitable radio-protector in radiotherapy patients and radiation workers.