magnetic resonance imaging property of doxorubicin-loaded gadolinium/13x zeolite/folic acid nanocomposite

Background: magnetic resonance imaging (mri) using nanostructures has been a proper method for tumor targeting purposes. different mri nanomaterials, targeting agents and anticancer drugs have been used for targeting of tumors. objectives: this study aims to consider the mri property of doxorubicin (dox)loaded gadolinium/13x zeolite/folic acid (gd^3+/13x/fa) nanocomposite.material and methods: in this in vitro study, gd^3+/13x/fa/dox nanocomposite was prepared and the xray diffraction, scanning electron microscopy and mtt assay were conducted to evaluate the physicochemical properties of the nanocomposite. mri was performed at 25°c using a 1.5 t clinical system to determine the t1 relaxation times and subsequently, the t1 relaxivity. results: the size of the nanocomposite was in the range of 80-200 nm. the nanocomposite without dox- loading (gd^3+/13x/fa) showed compatibility for a549 cells for all concentrations while dox-loaded nanocomposite was toxic for 62% of the cells at the concentration of 0.4 mg/ml. the t1 relaxivity of gd^3+/13x/fa/dox nanocomposite was 4.0401 mm^-1s^-1. conclusion: gd^3+/13x/fa/dox nanocomposite shows a t1 relaxivity similar to the conventional gadolinium chelates, and a successful dox loading.