goldcurcumin nanostructure in photothermal therapy on breast cancer cell line: 650 and 808 nm diode lasers as light sources

Background: au nanoparticles (aunps) exhibit very unique physiochemical and optical properties, which now are extensively studied in a range of medical diagnostic and therapeutic applications. aunps can be used for cancer clinical treatment with minimal invasion. on the other hand, curcumin is a polyphenol derived from turmeric which is used for medical purposes due to its anticancer, antimicrobial, antioxidant and antiinflammatory properties. despite these potential properties of curcumin, its usage is limited in medicine due to low solubility in water. conjugation of curcumin to aunps (aucur nanostructure) can be increasing its solubility. photothermal therapy (ptt) is a novel kind of cancer treatment which involves two major components: laser and photothermoconversion agents. materials and methods: here, diode lasers emitting 808 nm and 650 nm were utilized as light sources, and synthesized aucur nanostructure was applied as a photothermo conversion agent. uvvis absorbance spectroscopy and dynamic light scattering (dls) were applied to study the maximum absorption of particles, size stability of the samples and their zeta potential. the synthesized aucur nanostructure under irradiation of laser is used for ppt on 4t1 cells. the cytotoxicity activity of aucur nanostructure and laser irradiation on 4t1 cells was evaluated by mtt assay. results: synthesized aucur nanostructure showed λmax at 540 nm and a mean hydrodynamic diameter of 25.8 nm. 4t1 cells were exposed to an 808 nm diode laser (1.5 w cm2, 10 min) in the presence of different concentrations of aucur nanostructure. next, 4t1 cells with auvur nanostructure were exposed to diode laser beam (650 nm, 1.5 w cm2) for 10 min. the results revealed that aucur nanostructure under laser irradiation of 808 nm more decreased cell viability of 4t1 cells compared to laser irradiation of 650 nm. conclusion: it was concluded that combining an 808nm laser at a power density of 1.5w/cm2 with aucur nanostructure has a destruction effect on 4t1 breast cancer cells in vitro experiments compared to laser irradiation of 650 nm.