تاثیر مکمل آستاگزانتین بر عملکرد شناختی و افسردگی در بیماران مبتلا به دیابت نوع دو: یک کارآزمایی بالینی دوسوکور

ﻣﻘﺪﻣﻪ: ﻣﺼﺮف ﺧﻮراﮐﯽ آﺳﺘﺎﮔﺰاﻧﺘﯿﻦ از ﻃﺮﯾﻖ اﺛﺮات ﻣﻔﯿﺪ آن ﺑﺮ اﻟﺘﻬﺎب و اﺳﺘﺮس اﮐﺴﯿﺪاﺗﯿﻮ ﻣﯽﺗﻮاﻧﺪ ﻋﻼﺋﻢ اﻓﺴﺮدﮔﯽ و ﻋﻤﻠﮑﺮد ﺷﻨﺎﺧﺘﯽ را ﺑﻬﺒﻮد ﺑﺨﺸﺪ. ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﺑﻪﻣﻨﻈﻮر ﺗﻌﯿﯿﻦ اﺛﺮ آﺳﺘﺎﮔﺰاﻧﺘﯿﻦ ﺑﺮ ﻋﻼﯾﻢ اﻓﺴﺮدﮔﯽ و ﻋﻤﻠﮑﺮد ﺷﻨﺎﺧﺘﯽ ﺑﯿﻤﺎران ﻣﺒﺘﻼ ﺑﻪ دﯾﺎﺑﺖ ﻧﻮع 2 اﻧﺠﺎم ﺷﺪ. روشﻫﺎ: اﯾﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺎﻟﯿﻨﯽ ﺗﺼﺎدﻓﯽ ﮐﻨﺘﺮل ﺷﺪه دوﺳﻮﮐﻮر، ﺑﺮ روی 44 ﺑﯿﻤﺎر 30 ﺗﺎ 60 ﺳﺎﻟﻪ ﻣﺒﺘﻼ ﺑﻪ دﯾﺎﺑﺖ ﻧﻮع 2 اﻧﺠﺎم ﺷﺪ. ﺑﯿﻤﺎران ﺑﻪﻃﻮر ﺗﺼﺎدﻓﯽ ﺑﻪ ﻣﺪت 8 ﻫﻔﺘﻪ، روزاﻧﻪ 8 ﻣﯿﻠﯽﮔﺮم آﺳﺘﺎﮔﺰاﻧﺘﯿﻦ(22 ﻧﻔﺮ) و ﯾﺎ داروﻧﻤﺎ (22 ﻧﻔﺮ= روز) درﯾﺎﻓﺖ ﮐﺮدﻧﺪ. ﺗﻐﯿﯿﺮات اﻓﺴﺮدﮔﯽ و ﻋﻤﻠﮑﺮد ﺷﻨﺎﺧﺘﯽ ﺑﻪﺗﺮﺗﯿﺐ ﺗﻮﺳﻂ ﭘﺮﺳﺸﻨﺎﻣﻪ اﻓﺴﺮدﮔﯽ ﺑﮏ (bdi: beck depression inventory) (ii) و ﭘﺮﺳﺸﻨﺎﻣﻪ ﻋﻤﻠﮑﺮد ﺷﻨﺎﺧﺘﯽ ( msse: mini-mental state examination) ارزﯾﺎﺑﯽ ﺷﺪ. ﯾﺎﻓﺘﻪﻫﺎ: ﭘﺲ از 8 ﻫﻔﺘﻪ ﻣﺪاﺧﻠﻪ، ﻧﻤﺮه ﻋﻤﻠﮑﺮد ﺷﻨﺎﺧﺘﯽ ﻓﻘﻂ در ﮔﺮوه آﺳﺘﺎﮔﺰاﻧﺘﯿﻦ ﺑﻪﻃﻮر ﻣﻌﻨﯽداری ﺑﻬﺒﻮد ﯾﺎﻓﺖ (p<0/01). در ﻫﺮ دو ﮔﺮوه از ﻧﻈﺮ ﭘﺮﺳﺸﻨﺎﻣﻪ اﻓﺴﺮدﮔﯽ ﺑﮏ ﮐﺎﻫﺶ ﻣﻌﻨﯽداری ﻣﺸﺎﻫﺪه ﻧﺸﺪ. ﻧﺘﯿﺠﻪﮔﯿﺮی: ﺑﻪﻃﻮر ﮐﻠﯽ، ﻣﺼﺮف روزاﻧﻪ 8 ﻣﯿﻠﯽﮔﺮم ﻣﮑﻤﻞ آﺳﺘﺎﮔﺰاﻧﺘﯿﻦ در ﻃﯽ 8 ﻫﻔﺘﻪ، ﻣﯽﺗﻮاﻧﺪ اﺛﺮات ﻣﺜﺒﺘﯽ در ﺑﻬﺒﻮد ﻋﻤﻠﮑﺮد ﺷﻨﺎﺧﺘﯽ ﺑﯿﻤﺎران دﯾﺎﺑﺘﯽ داﺷﺘﻪ ﺑﺎﺷﺪ.

The Effect of Astaxanthin Supplementation on Cognitive Function and Depression in Patients with Type 2 Diabetes: A Double-blind, Randomised Controlled Trial

Background: Oral administration of astaxanthin may improve the symptoms of depression and cognitive function through its beneficial effects on inflammation and oxidative stress. This study was conducted to determine the effects of astaxanthin on depressive symptoms and cognitive performance in patients with type II diabetes mellitus.Methods: This doubleblind randomized placebocontrolled clinical study was performed on 44 patients with type II diabetes mellitus aged 3060 years. The patients were randomized into two groups to receive 8 mg astaxanthin (n=22) or placebo (n=22) daily for 8 weeks. Changes in depression and cognitive performance were assessed by Beck depression InventoryII (BDIII) and cognitive functioning questionnaire, respectively.Findings: After 8 weeks of intervention, the baseline cognitive function score was significantly improved only in the astaxanthin group during the study (P<0.01). However, there was no significant decrease in the BDIII score in any of the research groups.Conclusion: As the findings indicated, astaxanthin supplementation in diabetic patients had positive effects on cognitive function over 8 weeks.