Genetic Variation in MMP-1 Promoter Region and Breast Cancer Susceptibility.

Breast cancer forms from uncontrolled growth of abnormal breast cells, and its metastasis is one of the leading causes of death among women. mmp-1 is a member of matrix metalloproteinase genes family that is involved in many steps of cancer development and invasion. genetic variation in the mmp-1 promoter (insertion or deletion of a guanine) could modify the level of mmp-1 expression and taught to be a facile factor for tumor development and metastasis. the purpose of the present study is evaluation whether genetic variation in mmp-1 promoter could modify the susceptibility to development and metastasis of breastcancer. therefore, it could be considered as genetic marker for identification highly prone women for breast cancer initiation and/or invasion. for investigation of this hypothesis, we genotyped 200 women with breast cancer and 100 control subjects without any history of genetic disease using pcr-rflp. the median follow up of patients was 20 months. metastasis based analysis revealed that 2g/2g genotype had stronger correlation with metastasis group than m- group; both at the time of diagnosis (or=1.86, %95ci=1.0-3.64) and also at the end offollow-up duration (or=2.71, %95ci=1.43-5.11). our data suggest that 2g/2g homozygote polymorphism is involved in metastatic spread, but not in initiation of breast cancer.