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Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors
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نویسنده
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Rafinejad A. ,Fallah-Tafti A. ,Tiwari R. ,Foroumadi A. ,Akbarzadeh T.
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منبع
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Journal Of Sciences Islamic Republic Of Iran - 2015 - دوره : 26 - شماره : 4 - صفحه:321 -325
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چکیده
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In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their src kinase inhibitory activity. for this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. all compounds showed moderate activities comparing with staurosporine as the reference drug.
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کلیدواژه
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Ethyl 2 ,4-Dioxo-4-Arylbutanoates ,Src Kinase ,Cancer
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آدرس
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Tehran University Of Medical Sciences Tums, ایران, Tehran University Of Medical Sciences Tums, ایران, 2 Department Of Biomedical And Pharmaceutical Sciences, College Of Pharmacy, University Of Rhode Island, Kingston, Ri 02881, Usa, ایران, Tehran University Of Medical Sciences Tums, ایران, Tehran University Of Medical Sciences Tums, ایران
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Authors
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