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The Potential of 5-aminolevulinic Acid as a Contrast Agent in MR Imaging: Challenges and Opportunities
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نویسنده
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ebrahimpour a. ,riahi alam n. ,khoobi m.
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منبع
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journal of sciences islamic republic of iran - 2021 - دوره : 32 - شماره : 1 - صفحه:15 -28
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چکیده
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Nowadays, 5-aminolevulinic acid (5-ala) plays an influential role in the detection of malignant tumors as a photodynamic diagnosis tool. nevertheless, an outlook regarding 5-ala applicability in magnetic resonance imaging (mri) has recently emerged. many studies confirmed the impact of 5-ala on promoting intracellular heme synthesis and iron metabolism, which support the capability of 5-ala in mri owing to the susceptibility effect of iron. therefore, concerning the high safety and high affinity of 5-ala to tumor cells, 5-ala-based mri could be an intriguing method for malignant foci identification.
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کلیدواژه
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5-aminolevulinic acid; Magnetic resonance imaging; Protoporphyrin IX; Cellular iron metabolism; Transferrin receptor
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آدرس
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tehran university of medical sciences, faculty of medicine, department of medical physics and biomedical engineering, Iran, tehran university of medical sciences, faculty of medicine, department of medical physics and biomedical engineering, Iran, tehran university of medical sciences, the institute of pharmaceutical sciences (tips), biomaterials group, Iran
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پست الکترونیکی
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m-khoobi@tums.ac.ir; mehdi.khoobi@gmail.com
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Authors
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