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Synthesis and Biological Evaluation of 2-Phenyl Benzothiazole Derivatives as Cytotoxic Agents
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نویسنده
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firoozpour l. ,mokhtari a. ,moghimi s. ,safavi m. ,foroumadi a.
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منبع
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journal of sciences islamic republic of iran - 2018 - دوره : 29 - شماره : 4 - صفحه:335 -340
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چکیده
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Cancer is a leading cause of death worldwide. many heterocyclic cores are present in the structures of clinically approved anticancer drugs. meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, biologically evaluated against breast cancer cell line (t47d) and compared with etoposide as a reference drug. the anticancer activities were evaluated by mtt colorimetric assay. among all tested compounds, n-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)acetamide illustrated the most potent cytotoxic activity.
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کلیدواژه
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Phenyl benzothiazole; Thiobenzanilides; Jacobson synthesis; Cancer
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آدرس
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tehran university of medical sciences, drug design and development research center, Iran, tehran university of medical sciences, drug design and development research center, Iran, tehran university of medical sciences, drug design and development research center, Iran, iranian research organization for science and technology, department of biotechnology, Iran, kerman university of medical sciences, faculty of pharmacy, neuroscience research center, department of medicinal chemistry, Iran. tehran university of medical sciences, faculty of pharmacy, pharmaceutical sciences research center, department of medicinal chemistry, Iran
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پست الکترونیکی
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aforoumadi@yahoo.com
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Authors
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