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Synthesis of 4-(2-Methylthiazol-4-yl)- Hexahydroquinoline and 1,4-Dihydropyrimidin Derivatives
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نویسنده
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Foroughi Moghadam M.J. ,Amini M. ,Assadieskandar A. ,Shafiee A.
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منبع
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journal of sciences islamic republic of iran - 2011 - دوره : 22 - شماره : 1 - صفحه:21 -25
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چکیده
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A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol- 4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. the stereochemistry of 1,4-dihydropyrimidine derivatives were studied using 1hnmr.
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کلیدواژه
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4-Hexahydroquinoline; 1 ,4-Dihydropyrimidines; Thiazoles; 1 ,4-Dihydropyridine
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آدرس
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tehran university of medical sciences tums, Faculty of Pharmacy, Department of Medicinal Chemistry, ایران, tehran university of medical sciences tums, Drug Design & Development Research Center, ایران, tehran university of medical sciences tums, Faculty of Pharmacy, Department of Medicinal Chemistry, ایران, tehran university of medical sciences tums, Faculty of Pharmacy, Department of Medicinal Chemistry, ایران
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پست الکترونیکی
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ashafiee@ams.ac.ir
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Authors
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