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Synthesis and Antitubercular Activity of N^3,N^5-Diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-3,5-dicarboxamide
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نویسنده
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Shafii B ,Amini M ,Akbarzadeh T ,Shafiee A
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منبع
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journal of sciences islamic republic of iran - 2008 - دوره : 19 - شماره : 4 - صفحه:323 -328
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چکیده
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5-arylisoxazolyl-3-carboxaldehydes were condensed with n-aryl acetoacetamide and ammonium acetate in methanol to give n^3,n^5-diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-3,5-dicarboxamides. all compounds were screened for their antitubercular activity against mycobacterium tuberculosis (h37rv). the results for new synthesized compounds showed a moderate activity in comparison to rifampicin.
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کلیدواژه
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Dihydropyridine; 5-Arylisoxazole; Antituberculosis
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آدرس
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islamic azad university, Faculty of Pharmacy, Department of Medicinal Chemistry, ایران, tehran university of medical sciences tums, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, ایران, tehran university of medical sciences tums, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, ایران, tehran university of medical sciences tums, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, ایران
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پست الکترونیکی
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ashafiee@ams.ac.ir
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Authors
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