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Synthesis and Pharmacological Evaluation of Some Novel Isatin Derivatives for Antimicrobial Activity
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نویسنده
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Bari S.B. ,Agrawal A.O. ,Patil U. K.
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منبع
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journal of sciences islamic republic of iran - 2008 - دوره : 19 - شماره : 3 - صفحه:217 -221
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چکیده
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In the present work, a series of new 5-substituted-3-(4-arylimino)-1-[5-mercapto(1,3,4-oxadiazolyl)]-methyl-indol-2-one (4a-g) have been synthesized by heterocyclization of 5-substituted-3-(4-arylimino)-2-oxo-1-indole acetylhyrazide (3a-g) on treatment with cs2 in ethanolic koh. the compound 4a was characterized by its elemental analysis, ir, hnmr and mass spectroscopy. thesynthesized compounds (4a-g) were evaluated for in vitro antibacterial activity and antifungal activity against various strains of bacteria and fungi
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کلیدواژه
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Isatin; 1 ,4-Oxadiazole; Antibacterial; Antifungal
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آدرس
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R. C. Patel Institute of Pharmaceutical Education and Research, Department of Pharmaceutical Chemistry, India, R. C. Patel Institute of Pharmaceutical Education and Research, Department of Pharmaceutical Chemistry, India, R. C. Patel College of Arts, Science, Commerce, Department of Microbiology, India
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Authors
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