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Novel levofloxacin derivatives as potent antibacterial agents
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نویسنده
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moshafi m.h. ,bahador n. ,moghimi s. ,ejtemaei r. ,foroumadi a. ,asadipour a.
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منبع
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journal of sciences islamic republic of iran - 2017 - دوره : 28 - شماره : 2 - صفحه:127 -131
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چکیده
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In this report,a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against gram-positive (bacillus subtillis,staphylococcus aureus,staphylococcus epidermidis and micrococcus luteus) and gram-negative (esherichio coli,klebsiella pneumoniae,pseudomonas aeruginosa and serratia marcescens) organisms. the results showed that some of the synthesized compounds are strong antibacterial agents. all the synthesized compounds showed remarkable activities against staphylococcus epidermidis and staphylococcus aureus (mic = 0.03-1 μg/ml and 0.06-1 μg/ml respectively). © 2017,national research center of medical sciences. all rights reserved.
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کلیدواژه
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Antibacterial evaluation; Fluoroquinolone; Levofloxacin
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آدرس
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department of pharmaceutics,faculty of pharmacy and pharmaceutics research center,kerman university of medical sciences,kerman, ایران, department of pharmaceutics,faculty of pharmacy and pharmaceutics research center,kerman university of medical sciences,kerman, ایران, drug design and development research center,tehran university of medical sciences,tehran, ایران, drug design and development research center,tehran university of medical sciences,tehran, ایران, drug design and development research center,tehran university of medical sciences,tehran,iran,department of medicinal chemistry,faculty of pharmacy and neuroscience research center,kerman university of medical sciences,kerman, ایران, department of medicinal chemistry,faculty of pharmacy and neuroscience research center,kerman university of medical sciences,kerman, ایران
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Authors
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