Haemodynamic effects of fructose and sucralose in healthy,caucasian males

Objective: to determine the acute haemodynamic changes produced by the ingestion of fructose or sucralose solutions in water.setting: medical school,university of nottingham,queen's medical centre,nottingham,uk. material and methods: ten,healthy,non-smoking,white caucasian males,aged between 18-40 years ingested solutions containing fructose (0.75 g/kg body weight) or sucralose dissolved in 500 ml of water,on separate days. volunteers rested semi-recumbent on a bed in a thermo-regulated environment and a 'finometer' was used to record beat-to-beat blood pressure (bp),cardiac output (co),heart rate (hr),total peripheral resistance (tpr) and stroke volume (sv) for 30 min baseline,5 min during ingestion and for 60 min post ingestion.results: there was a significant rise in diastolic bp (dbp) and mean arterial pressure (map) from the baseline with fructose and sucralose drinks and in systolic bp (sbp) with the fructose drink (p < 0.05). trends for a rise in systolic bp (sucralose),tpr,hr and co (both fructose and sucralose) were observed. however,there was no statistically significant difference between the drinks containing either fructose or sucralose in the responses of the above variables. conclusion: ingestion of fructose and sucralose increases bp. sucralose produce effects that are similar but smaller than fructose.