Dietary phytoestrogen scoring database for prostate cancer studies and their role in prostate cancer risk

Objectives: to create a dietary isoflavones scoring database for future use in cancer epidemiologic studies. to investigate the role of isoflavones in aetiology of prostate cancer. materials and methods: a population based case- control study was conducted on 525 cases and 843 controls. to create an isoflavones scoring database,a creditable phytoestrogens database,and data from publications were used to create a mathematical computerised calculation program. then after obtaining isoflavone intake for each individual,an unconditional logistic regression with various models was carried out. results: there are 131 food items in the food frequency question (ffq). isoflavones values have been assigned to 56 items out of 131. the results of the analysis to explore the role of isoflavones either as a continuous or quintile variable were not significant,not a single quintile of isoflavones showed any significant association with prostate cancer risk. conclusion: the isoflavones scoring database has been created. the analysis of the young prostate cancer study dataset and the role of isoflavones in disease aetiology has not shown a statistically significant association.