Comparison of inter-appointment pain between ledermix and no intracanal medicament in acute apical periodontitis

Objective: to compare the mean difference in inter-appointment pain by using ledermix and no intracanal medicament in patients with acute apical peridontitis. material and methods: this randomized control trial was conducted at operative dentistry department of altamash institute of dental medicine,karachi during august 2009 to february 2010. patients after selection were divided into two groups by even-odd method. group 1: ledermix paste and group 2: no intracanal medicament (control group). the follow-up visit was scheduled and the mean inter-appointment pain was recorded after 48 hours on visual analogue scale. results: in 222 patients mean inter appointment pain was 9.0±0.71 in group 1 and 12.26 ± 0.90 in group 2. the mean difference between groups 3.26 ± 1.15 (95% ci of mean: 0.99 to 5.53). conclusion: patients with ledermix paste experienced significantly less postoperative pain than with no intracanal medicament (p=0.005) at 48 hours.