Prevalence of helicobacter pylori infection in patients with perforated peptic ulcer

Objectives: to determine the prevalence of helicobacter pylori infection in patients with perforated peptic ulcer. patients and methods: this prospective study was conducted in the department of surgery,(surgical unit-ii),liaquat university of medical & health sciences,jamshoro. all patients were evaluated by full history,clinical examination and relevant laboratory investigations including. x-ray chest and abdomen,ultrasound abdomen,serum anti h-pylori,biopsy and histo-pathology for detection of helicobacter pylori infection and perforation. the data was collected through pre-designed proforma and analyzed by spss version 10.00. results: during study period 75 patients were diagnosed as case of perforated peptic ulcer. male (73%) outnumber female (27%). majority of patients were more than 30 years of age with mean age of 44.6 years sd ± 9.89. the serological test for helicobacter pylori was positive in all 75 cases; however histopathology of biopsy yields h. pylori in 50 (66.6%) cases. on exploratory laparotomy perforated duodenal ulcer was found in 50 (67%) patients while 25(33%) patients had perforated gastric ulcer. conclusion: the biopsy proven prevalence of perforated peptic ulcer,one of the life-threatening complications of h. pylori,was is 67% in this study.