Vitamin D3 in newly diagnosed pulmonary tuberculosis patients: A comparative case control study

Objective: to evaluate vitamin d in pulmonary tuberculosis and normal healthy adults. study design: case control study. place and duration: department of medicine,isra university hospital hyderabad,from january 2013- june 2014. subjects & methods: a sample of 209 diagnosed pulmonary tuberculosis patients was selected through non-probability purposive sampling according to inclusion and exclusion criteria. after taking informed written consent from the participants,vitamin d was measured by architect i 1000 system for estimation of 25-oh-d3. the data was recorded on a pre-structured proforma,and analyzed on spss version 21.0. the significant p-value was taken at ≤ 0.05. results: the mean ±s.d serum level of 25-hydroxyvitamin d3 in cases and controls were 27.1±9.7 and 36.8±8.1 (ngdl-1) respectively (p=0.0001).the 25-hydroxyvitamin d3 levels as low as 6 ng/dl were observed in pulmonary tuberculosis subjects. the normal,insufficiency and deficiency of 25-hydroxyvitamin d3 were observed in 37(33%),16 (14.2%) and 59 (52.6%) in cases respectively compared to controls as 57 (58.7%),21(21.6%) and 19 (19.5%) respectively. conclusion: patients with pulmonary tuberculosis are significantly vitamin d deficient. vitamin d supplements may be prescribed,however further studies are warranted. © 2016,liaquat university of medical and health sciences. all rights reserved.