Clinico-pathological findings in myeloid malignancies: A single center experience

Introduction: myeloid malignancies are clonal disorders of hematopoietic stem/precursor cells. the criteria for the diagnosis of acute myeloid leukemia (aml) are based on morphological cytogenetic and flow-cytometric findings. the prognostic outcome with intensive chemotherapy is better than with non-intensive treatment. purpose/objectives: to determine the frequency of various clinical & pathological findings in myeloid malignancies. study design: cross sectional descriptive study. place and duration of study: the study was carried out at department of pathology from october 2014 to december 2016. material/patients and methods: detailed history,clinical and pathological findings recorded on a pre-designed proforma including bone marrow reports was evaluated. results: during period of study,351 proformas including bone marrow reports were evaluated,from which 49 (30 males and 19 females; age ranges between 03 months to 60 years) were diagnosed as myeloid malignancies. the distribution of myeloid malignancies were acute myeloid leukemia (n=21),chronic myeloid leukemia (n=14),acute myelodysplastic syndrome (n=3),myeloproliferative neoplasms (n=3),myelofibrosis (n=2),myeloid hyperplasia (n=2),acute promyelocytic leukemia (n=2),myelomonocytic leukemia (n=1),and transient abnormal myelopoiesis (n=1).the main presenting complaints were fever and weight loss,whereas splenomegaly was the most common finding on clinical examination. the commonest laboratory finding was anemia followed by leukocytosis; while 10 patients showed pancytopenia. conclusion: aml with fever and bicytopenia is the commonest myeloid malignancy in our series. © 2017,liaquat university of medical and health sciences. all rights reserved.