Comparison between S-allyl cysteine and gliclazide in lowering the blood glucose levels in diabetic rats

Background: diabetes mellitus is a global problem caused by the deficiency of insulin secretion either absolute or relative. treatment options are insulin and oral glucose lowering drugs. current study was designed to find out the glucose lowering properties of s-allylcysteine a garlic derivative sulfur containing amino acid. objective: to compare blood glucose lowering effects of s-allylcysteine with gliclazide in diabetic rat model. study design,place and duration: this 3 months animal study was carried out in animal house of isra university hyderabad from august 2014 to oct 2014. material and methods: 32 male wistar rats were randomly divided into 4 equal groups a,b,c and d after selection through non-probability purposive sampling. group a and b served as positive and negative controls respectively. diabetes was induced in group b,c and d by injecting alloxan at the dose of 120 mg/kg according to the weight of rats. rats in group c and d were treated with s-allylcysteine (150 mg/kg),gliclazide (5 mg/kg) respectively. random blood sugar levels of all groups were measured after weeks 1,2 & 3. the data was analyzed by spss version 21.0. results: blood glucose levels after 2nd and 3rd week were 264.3 ± 43.16 vs. 218.75 ± 36.38 (p=0.0001) for sac and 229.0 ± 89.87 vs. 241.0 ± 48.19 mg/dl for gliclazide (p=0.001) while at the end of 3rd week results for two control groups were non-significant statistically (p-0.07 and 0.09). conclusion: it is concluded that s-allylcysteine possess blood glucose lowering properties that are comparable to gliclazide. © 2017,liaquat university of medical and health sciences. all rights reserved.