Liver Function in Non - Pregnant Hyperthyroid Women: A Hospital Based Cross Sectional Study From Northern Pakistan

Introduction: functions of almost all body cells and organs are influenced by thyroid hormones; therefore malfunction of thyroid gland may cause serious clinical problems affecting major organs like liver and kidney. objective: the objective of the study was to evaluate the effect of hyperthyroidism on liver function. methodology: this hospital- based cross sectional study was conducted on 163 non-pregnant women in the age group of 18-75 years to evaluate the effects of hyperthyroidism on the biochemical markers of liver function. serum t3,t4,tsh and liver function tests were carried out using standard methods and kits. results: no significance differences were found in the alt (alaninetransaminase) and ast (aspartate transaminase) level in all the three groups. alt level was found to be 33.14 ±2.98 in oh (overtly hyperthyroid),29.50±1.69 in sh (sub clinically hyperthyroid) group as compared to 29.69 ±3.28 iu/l in n (normal) group. ast (aspartate transaminase) level was 33.70 ±5.12 i u/l in n group,30.68 ±2.7 in oh group and 30.38 ±2.6 i u/l in sh group. avery significant positive correlation was found between ast and tsh in the n group (p= 0.002) and bmi and t3 in n and oh group respectively (p=0.01). no significant correlation was found between liver enzymes and thyroid profile markers in any of the study groups. conclusion: the study shows that hyperthyroidism has no severe effects on liver function. © 2017,liaquat university of medical and health sciences. all rights reserved.