gastroprotective effect of oral powder containing probiotic metabolites on indomethacin-induced gastric ulcers in rats

Background: gastric ulcers are a prevalent chronic issue in the digestive system, incurring considerable financial costs. recent investigations have revealed that probiotics, such as lactobacilli, may serve as potential treatments for gastric ulcers. objectives: the present study aimed to investigate the gastroprotective effects of a powder containing lactobacillus casei metabolites against gastric ulcers induced by indomethacin in rats. methods: gastric ulcers were induced using indomethacin (30 mg/kg). wistar rats received pretreatment with a powder containing l. casei metabolites at doses of 60, 120, and 240 mg/kg, as well as ranitidine (50 mg/kg), 30 minutes prior to ulcer induction. at the conclusion of the experimental procedure, gastric ulcers, mucosal damage, lipid peroxidation [measured by malondialdehyde (mda) levels], and pro-inflammatory cytokine levels, specifically interleukin-6 (il-6), were assessed. results: the powder containing l. casei metabolites significantly reduced the number of ulcers, as well as mda levels and il-6, in a dose-dependent manner. the optimal dose for preventing gastric ulcers was found to be 120 mg/kg. conclusions: the findings of this study indicate that the powder containing l. casei metabolites effectively alleviates indomethacin-induced gastric ulceration, likely through its antioxidant and anti-inflammatory activities.