anti-inflammatory effect of aloe vera extract on inflammatory cytokines of rats fed with a high-fat diet (hfd)

Background: cytokines are glycoprotein compounds with an important role in inducing and regulating inflammation.objectives: the present study aimed to measure the effect of aloe vera alcoholic extracts on inflammatory cytokines in rats fed with a high-fat diet.methods: forty adult male wistar rats were purchased and randomly categorized into five groups, including two control groups (control and control fed a high-fat diet (hfd) and three experimental groups (high-fat diet + 150 mg/kg aloe vera, high fat diet + 300 mg/kg aloe vera, and high-fat diet + 600 mg/kg aloe vera). the rats in the experimental groups received high-fat emulsion and three doses of aloe vera for 60 days in the form of gavage. following blood sampling, serum concentrations of tumor necrosis factor-alpha (tnf-α), transforming growth factor-beta (tgf-β), interleukin 6 (il-6), and interferon-γ (inf-γ) were measured. statistical analysis was administered using spss-20 software by anova test. mean comparisons were conducted via duncan’s multiple range test at the 0.05 level of significance.results: the findings showed that a high-fat diet (hfd) could increase the concentrations of inflammatory factors tnf-α and tgf-β (p < 0.05). moreover, an increase in the concentration of inflammatory factor il-6 was observed at p < 0.01. no significant effects were observed in the mean concentration of inf-γ in the study groups. the use of aloe vera gel extract considerably reduced inflammatory factors tnf-α, tgf-β, and il-6 in the aloe vera extract-receiving groups.conclusions: in general, the results of the present study revealed that aloe vera alcoholic extract reduced inflammatory factors in the rats fed with a high-fat diet.