vitamin e and omega-3, 6 and 9 combinations versus vitamin e in the treatment of mastodynia

Background: breast pain or mastodynia is moderate to severe pain, which affects around 22 - 41% of women. if no anomaly is found and other causes, like nutritional changes, are excluded, many drugs, including herbal supplements, are recommended for the treatment of mastodynia. objectives: this study was performed to evaluate the effects of vitamin e and omega-3, 6 and 9 free fatty acids combinations versus vitamin e in women with mastodynia. patients and methods: a double blind, randomized clinical trial was conducted in shohada ashayer hospital in khorramabad lorestan province, in the vest of iran. a total of 88 women with symptoms of mastodynia, aged between 20 - 55 years old, were divided to two groups. the patients were randomly assigned to receive vitamin e (400 u/day) and vitamin e (400 u/day) plus omega-3, 6 and 9 (1200 mg/day) orally, for 3 months. results: vitamin e plus omega free fatty acids are more effective than the use of vitamin e alone in decreasing mastodynia. significant difference was seen between the cardiff breast score (cbs) of the vitamin e group compared to vitamin e - omega group (p < 0.05) at the end of the first, second and third months after treatment. conclusions: our results showed that vitamin e plus omega free fatty acids decrease the severity of mastodynia better than vitamin e alone.