antioxidant, antiglycation and anti-hyperlipidemic effects of trigonella foenum and cinnamon in type 2 diabetic rats

Background: diabetes is recognized as a common metabolic disorder, which is treated by different medicines. objectives: the aim of this study was to study the effect of trigonella foenum and cinnamon on glycation, some biochemical factors, liver histology and cholesterol 7-alpha hydroxylase activity in type 2 diabetic rats. methods: antiglycation and antioxidant ability were determined in vitro. male wistar diabetic rats were treated by 2 and 8% of cinnamon (w/w) and trigonella foenum. biochemical factors and liver enzymes were measured using enzymatic spectrophotometric methods. lipase and cholesterol 7-alpha hydroxylase activity were determined. liver lipid, antioxidant and morphological change were assessed. results: different concentrations of these plants (0.032, 0.065, 0.125, 0.25, 0.5 and 1mg/ ml) showed potential antiglycation ability. cinnamon and trigonella foenum significantly reduced advanced glycosylation end products (ages) and fructosamine formation, and also declined protein carbonyl contents and thiol group’s oxidation (p < 0.001). cinnamon and trigonella foenum extract in streptozotocin (stz)-induced diabetic rat normalized antioxidant capacity and lipid profile (p < 0.001). the cholesterol 7-alpha hydroxylase activity significantly increased following these plants administration. also, the liver histopathological changes were normalized in diabetic rats treated by cinnamon and trigonella foenum extract. conclusions: the findings illustrated that cinnamon and trigonella foenum extract improved hyperlipidemia and hyperglycemic. the hypolipidemic effect was likely by motivation of cholesterol 7-alpha hydroxylase activity. these plants also showed significant anti-diabetic effects in animal model by reducing blood glucose and inhibition of ages and fructosamine formation.