experimental and clinical evaluation of plantago australis extract as an anti-inflammatory agent to treat oral pathologies

Background: plantago australis is a native plant from southern brazil used to reduce inflammation. interestingly, there are no previous studies evaluating its use to treat oral lesions. objectives: the study aimed to investigate in vivo the anti-inflammatory activity of 10% ethanol extract of p. australis in recurrent aphthous stomatitis (ras), erosive lichen planus (elp) and actinic cheilitis (ac). methods: thirty patients with ras, elp and ac were treated topically with 10% p. australis solution-based or cream. results: in the comparison of in vivo data before and after the treatment and between different lesions, all p values were less than 0.05. conclusions: the pharmaceutical formulation of 10% p. australis was therapeutically effective in the subjects with inflammatory oral lesions of ras, elp and ac.