alteration effect of exendin-4 on oxidative stress and metabolic disorders induced by bisphenol a in adult male mice

Background: exendin-4 is a similar peptide to glp-1 and can interfere with various receptors of glp-1. bisphenol a (bpa), as an endocrine disruptor chemical, is used in a wide range of plastic products. objectives: the aim of this study was to clarify several exendin-4 aspects in treatment of metabolic disorders. methods: in in vivo condition, the bpa (100g/kg) and exendin-4 (4 nmol/kg/d) were administered for 20 days in four different groups, and blood glucose, insulin, lipid profile, adipocyte hormones and oxidative stress markers were examined. results: the results indicate that co-administration of exendin-4 and bpa modified hyperglycemia and hyperlipidemia induced by bpa. bisphenol a reduced antioxidant level, whereas exendin-4 improved these effects. conclusions: the findings of these studies suggest that the use of exendin-4 is useful in hyperglycemia, hyperlipidemia and metabolic disorders, induced by bpa.