sildenafil citrate can reduce pathological post-obstructive diuresis in a rat model ofbilateral ureteral obstruction

Objectives: the current study aimed at assessing the effect of oral sildenafil citrate on postobstructive diuresis and urinary electrolyte changes after resolution of bilateral ureteral obstruction (buo). methods: twenty-eight adult munich-wistar male rats were subjected to the surgical-induced buo for 24 hours. in intervention group (n = 14) sildenafil citrate 200 mg/kg food was administered from the operation day for 72 hours, while in control group (n = 14) no drug was used. daily urinary volume, urine sodium (meq/day), potassium (meq/day), and osmolality (mosm/kg h2o) were measured on the day before buo and for 2 days after buo release. results: in comparison to the control group, postobstructive diuresis was significantly lower in the sildenafil group (p value < 0.001), while urinary sodium and osmolality were both preserved better in this group (p value < 0.001); however, there were no significant difference in potassium level between the groups (p value = 0.285). conclusions: oral sildenafil citrate significantly decreased postobstructive diuresis and preserved urine sodium and osmolality near normal. these 2 effects mean a better preservation of renal function, while preventing pathological postobstructive diuresis.