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   Melatonin Effect on Immature Mouse Testicular Tissues, Vitrified-Thawed With Different Cryoprotectant Media  
   
نویسنده Gholami Mohammadreza ,Saki Ghasem ,Hemadi Masoud ,Khodadadi Ali ,Mohammadiasl Javad
منبع jentashapir journal of cellular and molecular biology - 2015 - دوره : 6 - شماره : 3 - صفحه:16 -20
چکیده    Conclusionsit seem that melatonin due to its antioxidant properties, if added to glycerol based media, reduces the harmful effects of freezing-thawing process, and protects seminiferous tubules histological structure from oxidative injury.resultsthe result showed that supplementation of glycerol based media with melatonin has reduced injury to histological structure of seminiferous tubules in the 6-day-old male balb/c mice pups testes (p = 0.004).backgroundfreezing of the immature testis tissue and then its transplantation can be considered a major step in fertility preservation for young boys with cancer.objectivesthe objective of this study was to investigate the antioxidant effects of melatonin on histological structure of seminiferous tubules that were vitrified-thawed with different cryoprotectant media.materials and methodsmale mice were randomly assigned to one of 10 experimental groups. testes of 6-day-old balb/c male mice pups were extracted and vitrified-thawed with different vitrification media with melatonin and without melatonin. then, their testes were stained with haematoxylin-eosin.
کلیدواژه Mouse;Testis;Melatonin;Vitrification
آدرس lorestan university of medical sciences, Razi Herbal Medicines Research Center, ایران, ahvaz jundishapur university of medical sciences, School of Medicine, Physiology Research Center, ایران, ahvaz jundishapur university of medical sciences, School of Medicine, Fertility, Infertility and Perinatology Research Center, ایران, ahvaz jundishapur university of medical sciences, School of Medicine, Department of Immunology, ایران, ahvaz jundishapur university of medical sciences, School of Medicine, Department of Medical Genetics, ایران
 
     
   
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