evaluation of glutathione redox status and inflammatory markers in icu patients with acute respiratory syndrome due to covid-19

Background: the use of biomarkers may significantly predict the need for special care and mortality risk in patients with covid-19. objectives: this study examines the glutathione redox status, inflammatory markers, and vitamin d levels in hospitalized covid-19 patients in the intensive care unit (icu). methods: a cohort of covid-19 patients (n = 16) was compared to a healthy control group. levels of reduced glutathione (gsh), oxidized glutathione (gssg), c-reactive protein (crp), interleukin-10 (il-10), interleukin-6 (il-6), cysteine, cystine, and vitamin d were measured using enzyme-linked immunosorbent assay (elisa). independent t-tests and cohen's d were employed to analyze differences. results: covid-19 patients exhibited significant differences from healthy controls in all measured indicators, including gsh, gssg, crp, il-10, il-6, cysteine, cystine, and the gsh/gssg ratio (p ≤ 0.001). additionally, all patients demonstrated vitamin d deficiency, with levels ranging from 10 to 20 ng/dl. ratios of gsh to gssg, il-6 to il-10, and crp to cysteine also indicated significant differences between covid-19 patients and healthy controls (p ≤ 0.001). conclusions: measurement of glutathione redox indicators, il-6 and il-10 levels, and their respective ratios, along with vitamin d and cysteine/cystine levels, could serve as effective predictors for timely interventions in covid-19 patients hospitalized in the icu.