the effect of 12 weeks of theraband resistance training on igf-1 and fgf-2 levels and their relationships with myokines on bone mineral density of osteosarcopenic obese women

Background: muscle-induced insulin-like growth factor 1 (igf-1) and fibroblast growth factor 2 (fgf-2) are important factors for muscle growth and maintenance. objectives: this study aimed to investigate the effect of 12 weeks of theraband resistance training on igf-1 and fgf-2 levels and their relationships with myokines on bone mineral density (bmd) in older women with osteosarcopenic obesity. methods: in this single-blind randomized clinical trial, 48 older women with osteosarcopenic obesity (mean age: 64.63 ± 3.68 years; fat percentage 45.4 ± 6.6%; bmi 33.1 ± 3.71 kg/m2; and t score of bone minerals density of femur and 1 - 4 lumbar spine -1.86 ± 1.42, based on the results of the dexa test) were randomly divided into control (n = 22) and training (n = 26) groups. the training group performed 12 weeks of theraband resistance training for all major muscle groups. blood samples were collected 48 hours before and 12 weeks after the intervention. results: after 12 weeks, a significant difference was observed in igf-1 (p = 0.033) levels in the training group compared to the control group. also, fgf-2 (p = 0.003) and igf-1 (p = 0.013) levels increased significantly in the training group. however, there was no significant relationship between igf-1 (p = 0.240) and fgf-2 (p = 0.806) levels and bmd. conclusions: theraband resistance training can be an appropriate training strategy to improve muscle mass in older adults with osteosarcopenic obesity by increasing igf-1 and fgf-2 levels.