association between paraoxonase1 (q192r and l55m) gene polymorphisms and risk of breast cancer: a meta-analysis of 12 studies

Background: the paraoxonase1 gene (pon1) is part of the paraoxonase family of multifactorial antioxidants (ec 3.1.1.2). the functional single-nucleotide polymorphisms l55m and q192r are located in the coding site of this gene. the association between these polymorphisms and breast cancer risk has been investigated, with contradictory results. objectives: a meta-analysis was done tofindthe association between pon1 (l55m and q192r) gene polymorphisms and breast cancer risk. methods:we searched embase, pubmed, andweb of science for related articles. twelve eligible studies before december 2021 were selected. statistical analysis was done by stata 14.0. result:we summarized 12 studies of l55m and q192r polymorphisms and breast cancer risk, involving 5,769 subjects (2,519 controls and 3,250 patients). in all genetic models, pon1-l55m polymorphisms were significantly associated with breast cancer risk. besides, pon1-q192r polymorphisms decreased breast cancer risk. the pon1-q192r allele reduced the cancer risk, particularly breast cancer (or (r vs. q): 0.7932). however, an association was found between the pon1-l55m allele and increased breast cancer risk (or (m vs. l): 1.6041). discussion: the results of 11 out of 12 studies were consistent with our results. in a non-conforming study, this was probably due to errors in conducting experiments. nonetheless, well-designed studies with more samples are needed to confirm our findings at protein levels.