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   dendrosomal nano-curcumin modulates p-glycoprotein activity and induces apoptosis in wild type and p53-mutant breast cancer cell lines  
   
نویسنده sobhkhizi aref ,babaei esmaeil ,azeez hewa jalal ,katiraee farzad ,hussen bashdar mahmud ,hoseinpour feizi mohammad ali
منبع jentashapir journal of cellular and molecular biology - 2020 - دوره : 11 - شماره : 4 - صفحه:1 -12
چکیده    Background: dendrosomal nano-curcumin (dnc) represents an enormous potential to serve as a therapeutic anticancer agent. here, we investigated the effect of dnc on wild type- and p53-mutant breast cancer cells. methods: mcf-7 and t47d cells were treated with dnc and investigated for cell viability through mtt assay. the mode of death was analyzed using annexin v/fitc staining and parp cleavage assays. flow cytometric efflux and cell swelling tests were employed to assess the p-glycoprotein (p-gp) transporter activity. moreover, real-time pcr was employed to study the expression of bax, bcl-2 as well as survivin and its δex3 splicing variant. results: our findings confirmed that dnc repressed cancer cell proliferation by induction of apoptosis. additionally, dnc significantly modulated p-gp function that might lead to improved cellular permanence of curcumin. malfunction of p-gp activity by dnc demonstrates its capability in reducing the drug resistance of p53-mutant cancer cells. conclusions: in conclusion, our findings demonstrated that dendrosomal nano-curcumin could be considered an anti-tumor therapeutic for p53-mutant tumor malignancies.
کلیدواژه curcumin ,dendrosome nanoparticles ,apoptosis ,p-glycoprotein ,p53-mutant
آدرس university of tabriz, faculty of natural sciences, department of animal biology, iran, university of tabriz, faculty of natural sciences, department of animal biology, iran, university of tabriz, faculty of natural sciences, department of animal biology, iran, university of tabriz, faculty of veterinary medicine, department of pathobiology, iran, hawler medical university, college of pharmacy, department of pharmacognosy, iraq, university of tabriz, faculty of natural sciences, department of animal biology, iran
پست الکترونیکی pourfeizi@tabrizu.ac.ir
 
     
   
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