hfe mutations c282y and h63d in iranian population with type 2 diabetes

Background: type 2 diabetes (t2d) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy.objectives: regarding the relationship between type 2 diabetes and hereditary chromatists, we conducted a genetic analysis on two previously reported mutations c282y and h63d related to the hfe gene in our population.patients and methods: altogether, 145 patients with type 2 diabetes and 145 healthy controls were examined. a genotyping assay performed using electrophoresis of the dna digestion products from mboi and rsai for h63d and c282y, respectively.results: results showed a significant difference between case and controls regarding c282y (p value < 0.001) and h63d genotypes (p value = 0.013). we also found a relationship between both mutations and nephropathy. moreover, the difference between c282y genotypes of patients with retinopathy and healthy controls were statistically significant (p value = 0.020) while there was no association between h63d and retinopathy. in addition, observed differences of both mutations were significant when nephropathic patients compared to the controls.conclusions: our study showed a significant association between h63d and c282y mutations and the risk of type 2 diabetes in iranian population.