effect of high-intensity interval training on the levels of liver fat transporter proteins (lfab and cd36) in rats with fatty liver

Background: non-alcoholic fatty liver disease (nafld) is the most prevalent chronic liver condition linked to a rise in other metabolic disorders, such as type 2 diabetes and metabolic syndrome. methods: thirty 5-week-old rats with an average body weight of 165.4 ± 31.3 g were randomly assigned into two main groups: a sham group (10 rats) and an experimental group (20 rats, including control for fatty liver and exercise + fatty liver subgroups). the high-intensity interval training (hiit) group underwent a hiit protocol for 8 weeks, training 5 days per week. the data were analyzed using a dependent t-test and one-way analysis of variance (anova), followed by bonferroni's post hoc test. results: non-alcoholic fatty liver disease significantly increased cd36 and lfabp levels in liver tissue (p = 0.023 and p = 0.001, respectively). eight weeks of interval training significantly decreased the levels of cd36 and lfabp in liver tissue (p = 0.019 and p = 0.007, respectively). conclusions: the onset of non-alcoholic fatty liver elevates fatty acid transporter levels in liver tissue. however, eight weeks of hiit markedly reduces these transporter levels.